JNCI J Natl Cancer Inst 111(6):538549 Li F, Emmerton KK, Jonas M, Zhang X, Miyamoto JB, Setter JR, Nicholas ND, Okeley NM, Lyon RP, Benjamin DR, Law C-L (2016) Intracellular released payload influences potency and bystander-killing effects of antibody-drug conjugates in preclinical models
This enzymatic recycling of GSH enhances the sensitivity of the assay
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Additionally, activation of CD38 in post-ischemic heart injury can severely deplete NADPH, impairing eNOS function and disrupting NADPH-dependent BH 4 salvage and synthesis (Reyes et al., 2015)
No published paper proposes this combination, describes a preparation containing these three species, or reports an experiment in which they were applied together